015 Bcl-2 family members as potential therapeutic targets for hidradenitis suppurativa
نویسندگان
چکیده
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of unknown etiology affecting over 1% the US population. Deep epidermal infiltrative cysts and tunnels characteristic develop in intertriginous skin, with mixed immune infiltrate present inflamed regions, dominated by B T cells, but also including myeloid cells. Recent studies show progressive increase cells plasma as HS lesions evolve towards end-stage disease. Moreover, transcriptomics ex-vivo patient data demonstrates that anti-TNFα therapy induces marked decrease cell compartment. Increasing bodies support role derived autoantibodies driving aspects HS. However, limited clinical only modest significant improvements symptoms inflammation anti-CD20 treatment. Further analysis revealed non-response associated hyperactive BCL2 genetic variant heightened molecular signature. These findings suggested for Bcl-2 family function responses Bcl-XL expression lesion significantly upregulated using histology RNA-seq analysis. Notably, infiltrating T-cells express both Bcl-XL, whereas diseased keratinocytes demonstrate dramatic shift from to Bcl-XL. Most importantly, bulk was localized on CD20+ CD138+plasma were predominantly expressing appeared occupy different anatomical niches lesions. Taken together, these suggest inhibition Bcl-2/Bcl-XL pathway, targeting pathogenic compartment, might effectively treat patients, non-responders.
منابع مشابه
A family study of hidradenitis suppurativa.
A family study of hidradenitis suppurativa was undertaken based on 26 subjects with the disease. The probands were obtained from Hospital Activity Analysis (HAA) records for a three year period (1980 to 1983) and by direct referral from hospital specialists over a six month period (1983 to 1984). Family pedigree information was collected by home visits or hospital interviews and confirmation of...
متن کاملHidradenitis suppurativa.
BACKGROUND Hidradenitis suppurativa is a chronic, recurrent, suppurative cutaneous disease. Despite its incidence, optimal medical or surgical treatment remains unclear. This review describes the disease, ranging from pathogenesis to treatment and prognosis. METHODS Articles were sourced from PubMed and Medline, using the MeSH terms 'hidradenitis suppurativa' and 'acne inversa'. Selection of ...
متن کاملKinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma.
Malignant pleural mesothelioma (MPM) is a rare and aggressive form of cancer commonly associated with asbestos exposure that stems from the thoracic mesothelium with high mortality rate. Currently, treatment options for MPM are limited, and new molecular targets for treatments are urgently needed. Using quantitative reverse transcription-polymerase chain reaction (RT-PCR) and an RNA interferenc...
متن کاملHidradenitis suppurativa.
Hidradenitis suppurativa is a chronic, relapsing, inflammatory disease process that primarily involves the axilla and/or inguinal region and does not manifest itself until after puberty. Typically, the process begins as a local occlusive disease of a sweat gland; secondary bacterial infection then occurs. The early stages of hidradenitis suppurativa are usually managed by the dermatologist. Onc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2023
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2023.03.016